I have also similar configuration and facing issue with Exchange 2010 Backup. The configuration is as follow: 2 x CAS NLB (hubs) under Windows 2008 R2 (physical) 1 x DAG (with 2 x physical Mail Servers) under Windows 2008 R2 (virtual) 1 x Master server NetBackup 7.0.1 under Windows 2003 R2 2 x Media Servers NetBackup 7.0.1 under Windows 2008 R2
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